Seroatlas · Human Serome Atlas

OR1F1

Olfactory receptor 1F1

Also known as: Olfmf, OR16-36, OR16-37, OR16-88, OR16-89, OR16-90, OR1F1_HUMAN, OR1F10, OR1F13P, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9, OR3-145

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43749
Gene: OR1F1
Ensembl: ENSG00000168124
Chromosome: 16
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>O43749|OR1F1
     1  MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS IDSCLHTPMY
    61  FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ MYFVFMFVDM DNFLLAVMAY
   121  DHFVAVCHPL HYTAKMTHQL CALLVAGLWV VANLNVLLHT LLMAPLSFCA DNAITHFFCD
   181  VTPLLKLSCS DTHLNEVIIL SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST
   241  CGSHLAVVLL FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA
   301  LKKVVGRVVF SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1F1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 3.2 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 3.2 nTPM
basal ganglia: 0.7 nTPM
testis: 0.6 nTPM
cerebral cortex: 0.5 nTPM
hippocampal formation: 0.5 nTPM
hypothalamus: 0.4 nTPM

Single-cell type

late spermatids: 57 nCPM
early spermatids: 43 nCPM
cardiomyocytes: 9 nCPM
late primary spermatocytes: 5.4 nCPM
retinal ganglion cells: 3.9 nCPM
neutrophils: 3.6 nCPM

Immune cell

eosinophil: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 5.9 nTPM
cerebral cortex: 4.8 nTPM
hippocampal formation: 4.5 nTPM
pons: 3.6 nTPM
basal ganglia: 3.2 nTPM
medulla oblongata: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -2.46
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1F1 as an antibody target. Whether an autoantibody or antibody against OR1F1 could matter depends on whether native OR1F1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1F1 is annotated at the cell surface, where native OR1F1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1F1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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