Seroatlas · Human Serome Atlas

OR1E2

Olfactory receptor 1E2

Also known as: OR17-135, OR17-93, OR1E2_HUMAN, OR1E4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47887
Gene: OR1E2
Ensembl: ENSG00000127780
Chromosome: 17
Canonical length: 323 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P47887|OR1E2
     1  MMGQNQTSIS DFLLLGLPIQ PEQQNLCYAL FLAMYLTTLL GNLLIIVLIR LDSHLHTPVY
    61  LFLSNLSFSD LCFSSVTMPK LLQNMQNQDP SIPYADCLTQ MYFFLYFSDL ESFLLVAMAY
   121  DRYVAICFPM HYTAICFLLH YTAIMSPMLC LSVVALSWVL TTFHAMLHTL LMARLCFCAD
   181  NVIPHFFCDM SALLKLACSD TRVNEWVIFI MGGLILVIPF LLILGSYARI VSSILKVPSS
   241  KGICKAFSTC GSHLSVVSLF YGTVIGLYLC PSANSSTLKD TVMAMMYTVV TPMLTPFIYS
   301  LRNRDMKGAL ERVICKRKNP FLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

schwann cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.7 nTPM
thalamus: 1.1 nTPM
basal ganglia: 0.6 nTPM
cerebral cortex: 0.6 nTPM
medulla oblongata: 0.6 nTPM
hypothalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.29
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1E2 as an antibody target. Whether an autoantibody or antibody against OR1E2 could matter depends on whether native OR1E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1E2 is annotated at the cell surface, where native OR1E2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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