Seroatlas · Human Serome Atlas

OR1D2

Olfactory receptor 1D2

Also known as: OLFR1, OR17-4, OR1D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P34982
Gene: OR1D2
Ensembl: ENSG00000184166
Chromosome: 17
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>P34982|OR1D2
     1  MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY
    61  FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY
   121  DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE
   181  MYVLLRMACS NIQINHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST
   241  CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL
   301  GRLLDKHFKR LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 2.2 nTPM

Expression across tissuesHPA

Tissue

retina: 2.2 nTPM
bone marrow: 1.4 nTPM
thyroid gland: 1.2 nTPM
choroid plexus: 1 nTPM
epididymis: 1 nTPM
skin: 1 nTPM

Single-cell type

early primary spermatocytes: 2.4 nCPM
early spermatids: 2.4 nCPM
epididymal clear cells: 2 nCPM
endometrial secretory cells: 0.3 nCPM
mast cells: 0.3 nCPM
undifferentiated spermatogonia: 0.3 nCPM

Immune cell

neutrophil: 0.6 nTPM
basophil: 0.2 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

white matter: 16 nTPM
cerebral cortex: 16 nTPM
cerebellum: 15 nTPM
hypothalamus: 15 nTPM
basal ganglia: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.46
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1D2 as an antibody target. Whether an autoantibody or antibody against OR1D2 could matter depends on whether native OR1D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1D2 is annotated at the cell surface, where native OR1D2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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