Seroatlas · Human Serome Atlas

OR1A1

Olfactory receptor 1A1

Also known as: OR17-7, OR1A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1Q5
Gene: OR1A1
Ensembl: ENSG00000172146
Chromosome: 17
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9P1Q5|OR1A1
     1  MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVRLHNPMY
    61  FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ MYFMIALGNT DSYILAAMAY
   121  DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD
   181  ITPLLKLSCS DIHFHVKMMY LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC
   241  GSHLTVVSLY YGTVMGTYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDMKAALR
   301  KLFNKRISS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

retina: 1.3 nTPM
bone marrow: 1.1 nTPM
salivary gland: 0.6 nTPM
skin: 0.6 nTPM
testis: 0.5 nTPM
duodenum: 0.4 nTPM

Single-cell type

thymocytes: 2.5 nCPM
kupffer cells: 1 nCPM
undifferentiated spermatogonia: 0.8 nCPM
foveolar cells: 0.4 nCPM
microglia: 0.3 nCPM
nk-cells: 0.2 nCPM

Immune cell

basophil: 1 nTPM
neutrophil: 0.4 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.2 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 33 nTPM
white matter: 30 nTPM
basal ganglia: 26 nTPM
hippocampal formation: 26 nTPM
thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.6
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1A1 as an antibody target. Whether an autoantibody or antibody against OR1A1 could matter depends on whether native OR1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1A1 is annotated at the cell surface, where native OR1A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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