Seroatlas · Human Serome Atlas

OR14J1

Olfactory receptor 14J1

Also known as: hs6M1-28, O14J1_HUMAN, OR5U1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGF5
Gene: OR14J1
Ensembl: ENSG00000204695
Chromosome: 6
Canonical length: 321 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q9UGF5|OR14J1
     1  MVNLTSMSGF LLMGFSDERK LQILHALVFL VTYLLALTGN LLIITIITVD RRLHSPMYYF
    61  LKHLSLLDLC FISVTVPQSI ANSLMGNGYI SLVQCILQVF FFIALASSEV AILTVMSYDR
   121  YAAICQPLHY ETIMDPRACR HAVIAVWIAG GLSGLMHAAI NFSIPLCGKR VIHQFFCDVP
   181  QMLKLACSYE FINEIALAAF TTSAAFICLI SIVLSYIRIF STVLRIPSAE GRTKVFSTCL
   241  PHLFVATFFL SAAGFEFLRL PSDSSSTVDL VFSVFYTVIP PTLNPVIYSL RNDSMKAALR
   301  KMLSKEELPQ RKMCLKAMFK L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR14J1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

retina: 1.7 nTPM
bone marrow: 0.9 nTPM
skin: 0.7 nTPM
testis: 0.6 nTPM
liver: 0.5 nTPM
appendix: 0.4 nTPM

Single-cell type

ependymal cells: 63 nCPM
brain excitatory neurons: 0.7 nCPM
brain inhibitory neurons: 0.3 nCPM
cdc: 0.1 nCPM
choroid plexus epithelial cells: 0.1 nCPM
loop of henle epithelial cells: 0.1 nCPM

Immune cell

basophil: 1 nTPM
neutrophil: 0.6 nTPM
naive B-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM

Brain region

cerebellum: 39 nTPM
cerebral cortex: 37 nTPM
white matter: 37 nTPM
midbrain: 30 nTPM
basal ganglia: 30 nTPM
amygdala: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR14J1 as an antibody target. Whether an autoantibody or antibody against OR14J1 could matter depends on whether native OR14J1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR14J1 is annotated at the cell surface, where native OR14J1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR14J1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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