Seroatlas · Human Serome Atlas

OR14C36

Olfactory receptor 14C36

Also known as: O14CZ_HUMAN, OR5BF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHC7
Gene: OR14C36
Ensembl: ENSG00000177174
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NHC7|OR14C36
     1  MPNSTTVMEF LLMRFSDVWT LQILHSASFF MLYLVTLMGN ILIVTVTTCD SSLHMPMYFF
    61  LRNLSILDAC YISVTVPTSC VNSLLDSTTI SKAGCVAQVF LVVFFVYVEL LFLTIMAHDR
   121  YVAVCQPLHY PVIVNSRICI QMTLASLLSG LVYAGMHTGS TFQLPFCRSN VIHQFFCDIP
   181  SLLKLSCSDT FSNEVMIVVS ALGVGGGCFI FIIRSYIHIF STVLGFPRGA DRTKAFSTCI
   241  PHILVVSVFL SSCSSVYLRP PAIPAATQDL ILSGFYSIMP PLFNPIIYSL RNKQIKVAIK
   301  KIMKRIFYSE NV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR14C36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

prostate: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.7 nTPM
pons: 0.5 nTPM
cerebral cortex: 0.4 nTPM
medulla oblongata: 0.4 nTPM
basal ganglia: 0.3 nTPM
hypothalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.05
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR14C36 as an antibody target. Whether an autoantibody or antibody against OR14C36 could matter depends on whether native OR14C36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR14C36 is annotated at the cell surface, where native OR14C36 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR14C36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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