Seroatlas · Human Serome Atlas

OR14A2

Olfactory receptor 14A2

Also known as: O14A2_HUMAN, OR5AX1, OR5AX1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96R54
Gene: OR14A2
Ensembl: ENSG00000241128
Chromosome: 1
Canonical length: 314 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q96R54|OR14A2
     1  MANVTLVTGF LLMGFSNIQK LRILYGVLFL LIYLAALMSN LLIITLITLD VKLQTPMYFF
    61  LKNLSFLDVF LVSVPIPKFI VNNLTHNNSI SILGCAFQLL LMTSFSAGEI FILTAMSYDR
   121  YVAICCPLNY EVIMNTGVCV LMASVSWAIG GLFGTAYTAG TFSMPFCGSS VIPQFFCDVP
   181  SLLRISCSET LMVIYAGIGV GACLSISCFI CIVISYIYIF STVLKIPTTK GQSKAFSTCF
   241  PHLTVFTVFI ITAYFVYLKP PSNSPSVIDR LLSVIYTVMP PVFNPVTYSL RNNDMKCALI
   301  RLLQKTYGQE AYFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR14A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

testis: 2.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 30 nCPM
early spermatids: 17 nCPM
adipocytes: 7.4 nCPM
late spermatids: 6.1 nCPM
hematopoietic stem cells: 5.3 nCPM
epicardial cells: 4.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.7 nTPM
medulla oblongata: 0.5 nTPM
hypothalamus: 0.4 nTPM
midbrain: 0.4 nTPM
amygdala: 0.3 nTPM
cerebral cortex: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.83

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR14A2 as an antibody target. Whether an autoantibody or antibody against OR14A2 could matter depends on whether native OR14A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR14A2 is annotated at the cell surface, where native OR14A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR14A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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