Seroatlas · Human Serome Atlas

OR14A16

Olfactory receptor 14A16

Also known as: O14AG_HUMAN, OR5AT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHC5
Gene: OR14A16
Ensembl: ENSG00000196772
Chromosome: 1
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q8NHC5|OR14A16
     1  MANLTIVTEF ILMGFSTNKN MCILHSILFL LIYLCALMGN VLIIMITTLD HHLHTPVYFF
    61  LKNLSFLDLC LISVTAPKSI ANSLIHNNSI SFLGCVSQVF LLLSSASAEL LLLTVMSFDR
   121  YTAICHPLHY DVIMDRSTCV QRATVSWLYG GLIAVMHTAG TFSLSYCGSN MVHQFFCDIP
   181  QLLAISCSEN LIREIALILI NVVLDFCCFI VIIITYVHVF STVKKIPSTE GQSKAYSICL
   241  PHLLVVLFLS TGFIAYLKPA SESPSILDAV ISVFYTMLPP TFNPIIYSLR NKAIKVALGM
   301  LIKGKLTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR14A16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

retina: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

tuft cells: 12 nCPM
cone photoreceptor cells: 4.1 nCPM
hematopoietic stem cells: 1.9 nCPM
gastric progenitor cells: 1.3 nCPM
early spermatids: 1.2 nCPM
adipocytes: 1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.4 nTPM
pons: 0.4 nTPM
medulla oblongata: 0.3 nTPM
cerebral cortex: 0.2 nTPM
spinal cord: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.11
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR14A16 as an antibody target. Whether an autoantibody or antibody against OR14A16 could matter depends on whether native OR14A16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR14A16 is annotated at the cell surface, where native OR14A16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR14A16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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