Seroatlas · Human Serome Atlas

OR13D1

Olfactory receptor 13D1

Also known as: O13D1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGV5
Gene: OR13D1
Canonical length: 346 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR13D1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q8NGV5|OR13D1
     1  MYRFTDFDVS NISIYLNHVL FYTTQQAGDL EHMETRNYSA MTEFFLVGLS QYPELQLFLF
    61  LLCLIMYMII LLGNSLLIII TILDSRLHTP MYFFLGNLSF LDICYTSSSI PPMLIIFMSE
   121  RKSISFIGCA LQMVVSLGLG STECVLLAVM AYDHYVAICN PLRYSIIMNG VLYVQMAAWS
   181  WIIGCLTSLL QTVLTMMLPF CGNNVIDHIT CEILALLKLV CSDITINVLI MTVTNIVSLV
   241  ILLLLIFISY VFILSSILRI NCAEGRKKAF STCSAHSIVV ILFYGSALFM YMKPKSKNTN
   301  TSDEIIGLSY GVVSPMLNPI IYSLRNKEVK EAVKKVLSRH LHLLKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR13D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

cardiomyocytes: 0.2 nCPM
retinal bipolar cells: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.4 nTPM
pons: 2.3 nTPM
basal ganglia: 2.1 nTPM
cerebral cortex: 2 nTPM
medulla oblongata: 1.9 nTPM
midbrain: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0.01
gnomAD missense Z: -0.48
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR13D1 as an antibody target. Whether an autoantibody or antibody against OR13D1 could matter depends on whether native OR13D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR13D1 is annotated at the cell surface, where native OR13D1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR13D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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