Seroatlas · Human Serome Atlas

OR13C3

Olfactory receptor 13C3

Also known as: O13C3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGS6
Gene: OR13C3
Canonical length: 347 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR13C3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q8NGS6|OR13C3
     1  MIVQLICTVC FLAVNTFHVR SSFDFLKADD MGEINQTLVS EFLLLGLSGY PKIEIVYFAL
    61  ILVMYLVILI GNGVLIIASI FDSHFHTPMY FFLGNLSFLD ICYTSSSVPS TLVSLISKKR
   121  NISFSGCAVQ MFFGFAMGST ECLLLGMMAF DRYVAICNPL RYPIILSKVA YVLMASVSWL
   181  SGGINSAVQT LLAMRLPFCG NNIINHFACE ILAVLKLACA DISLNIITMV ISNMAFLVLP
   241  LMVIFFSYMF ILYTILQMNS ATGRRKAFST CSAHLTVVII FYGTIFFMYA KPKSQDLIGE
   301  EKLQALDKLI SLFYGVVTPM LNPILYSLRN KDVKAAVKYL LNKKPIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR13C3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

innate lymphoid cells: 0.4 nCPM
other brain neurons: 0.4 nCPM
brain inhibitory neurons: 0.2 nCPM
ependymal cells: 0.2 nCPM
lactotrophs: 0.2 nCPM
megakaryocyte-erythroid progenitors: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 1.1 nTPM
medulla oblongata: 0.9 nTPM
white matter: 0.8 nTPM
hypothalamus: 0.7 nTPM
basal ganglia: 0.6 nTPM
cerebral cortex: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.58
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR13C3 as an antibody target. Whether an autoantibody or antibody against OR13C3 could matter depends on whether native OR13C3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR13C3 is annotated at the cell surface, where native OR13C3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR13C3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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