Seroatlas · Human Serome Atlas

OR13C2

Olfactory receptor 13C2

Also known as: O13C2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGS9
Gene: OR13C2
Ensembl: ENSG00000276119
Chromosome: 9
Canonical length: 318 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q8NGS9|OR13C2
     1  MEWENHTILV EFFLKGLSGH PRLELLFFVL IFIMYVVILL GNGTLILISI LDPHLHTPMY
    61  FFLGNLSFLD ICYTTTSIPS TLVSFLSERK TISLSGCAVQ MFLGLAMGTT ECVLLGMMAF
   121  DRYVAICNPL RYPIIMSKDA YVPMAAGSWI IGAVNSAVQS VFVVQLPFCR NNIINHFTCE
   181  ILAVMKLACA DISDNEFIML VATTLFILTP LLLIIVSYTL IIVSIFKISS SEGRSKASST
   241  CSAHLTVVII FYGTILFMYM KPKSKETLNS DDLDATDKII SMFYGVMTPM MNPLIYSLRN
   301  KDVKEAVKHL LNRRFFSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR13C2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 0.4 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 0.4 nCPM
gonadotrophs: 0.2 nCPM
other brain neurons: 0.1 nCPM
somatotrophs: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 2.2 nTPM
medulla oblongata: 1.4 nTPM
white matter: 1.2 nTPM
thalamus: 1.1 nTPM
midbrain: 0.9 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0.01
gnomAD missense Z: -1.32
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR13C2 as an antibody target. Whether an autoantibody or antibody against OR13C2 could matter depends on whether native OR13C2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR13C2 is annotated at the cell surface, where native OR13C2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR13C2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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