Seroatlas · Human Serome Atlas

OR13A1

Olfactory receptor 13A1

Also known as: O13A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGR1
Gene: OR13A1
Ensembl: ENSG00000256574
Chromosome: 10
Canonical length: 328 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

328 residues, UniProt reviewed canonical sequence.

>Q8NGR1|OR13A1
     1  MKLWMESHLI VPETRPSPRM MSNQTLVTEF ILQGFSEHPE YRVFLFSCFL FLYSGALTGN
    61  VLITLAITFN PGLHAPMYFF LLNLATMDII CTSSIMPKAL ASLVSEESSI SYGGCMAQLY
   121  FLTWAASSEL LLLTVMAYDR YAAICHPLHY SSMMSKVFCS GLATAVWLLC AVNTAIHTGL
   181  MLRLDFCGPN VIIHFFCEVP PLLLLSCSST YVNGVMIVLA DAFYGIVNFL MTIASYGFIV
   241  SSILKVKTAW GRQKAFSTCS SHLTVVCMYY TAVFYAYISP VSGYSAGKSK LAGLLYTVLS
   301  PTLNPLIYTL RNKEVKAALR KLFPFFRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR13A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 1 nTPM
spleen: 0.7 nTPM
cerebellum: 0.6 nTPM
thymus: 0.6 nTPM
small intestine: 0.5 nTPM
esophagus: 0.4 nTPM

Single-cell type

papillary tip epithelial cells: 1.6 nCPM
oligodendrocyte progenitor cells: 0.5 nCPM
brain excitatory neurons: 0.4 nCPM
brain inhibitory neurons: 0.3 nCPM
microglia: 0.3 nCPM
oligodendrocytes: 0.3 nCPM

Immune cell

memory B-cell: 0.4 nTPM
naive CD8 T-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -1.1
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR13A1 as an antibody target. Whether an autoantibody or antibody against OR13A1 could matter depends on whether native OR13A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR13A1 is annotated at the cell surface, where native OR13A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR13A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...