OR12D2

Protein identityUniProt · HPA

UniProt accession

P58182

Gene

OR12D2

Ensembl

ENSG00000280236

Chromosome

6

Canonical length

307 aa

Protein class

G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>P58182|OR12D2
     1  MLNTTSVTEF LLLGVTDIQE LQPFLFVVFL TIYFISVTGN GAVLMIVISD PRLHSLMYFF
    61  LGNLSYLDIC YSTVTLPKML QNFLSTHKAI SFLGCISQLH FFHSLGSTES MLFAVMAFDL
   121  SVAICKPLRY TVIMNPQLCT QMAITIWVIG FFHALLHSVM TSRLNFCGSN RIHHFLCDIK
   181  PLLKLACGNT ELNQWLLSTV TGTIAMGPFF LTLLSYFYII TYLFFKTRSC SMLCKALSTC
   241  ASHFMVVILF YAPVLFTYIH PALESFMDQD RIVAIMYTVV TPVLNPLIYT LRNKEVKGAL
   301  GRVIRRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR12D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

0.2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.81

gnomAD pLI

0.68

gnomAD missense Z

0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• detection of chemical stimulus involved in sensory perception of smell

Molecular functions

• G protein-coupled receptor activity
• odorant binding
• olfactory receptor activity

Cellular components

• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• Olfactory receptor
• GPCR, rhodopsin-like, 7TM
• Olfactory G-protein coupled receptor
• Olfactory receptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Olfaction
• Receptor
• Sensory transduction
• Transducer
• Transmembrane
• Transmembrane helix