Seroatlas · Human Serome Atlas

OR10R2

Olfactory receptor 10R2

Also known as: O10R2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGX6
Gene: OR10R2
Canonical length: 335 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR10R2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q8NGX6|OR10R2
     1  MPQILIFTYL NMFYFFPPLQ ILAENLTMVT EFLLLGFSSL GEIQLALFVV FLFLYLVILS
    61  GNVTIISVIH LDKSLHTPMY FFLGILSTSE TFYTFVILPK MLINLLSVAR TISFNCCALQ
   121  MFFFLGFAIT NCLLLGVMGY DRYAAICHPL HYPTLMSWQV CGKLAAACAI GGFLASLTVV
   181  NLVFSLPFCS ANKVNHYFCD ISAVILLACT NTDVNEFVIF ICGVLVLVVP FLFICVSYLC
   241  ILRTILKIPS AEGRRKAFST CASHLSVVIV HYGCASFIYL RPTANYVSNK DRLVTVTYTI
   301  VTPLLNPMVY SLRNKDVQLA IRKVLGKKGS LKLYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

enterocytes: 0.2 nCPM
erythrocyte progenitors: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM
astrocytes: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
early spermatids: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: -0.69
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10R2 as an antibody target. Whether an autoantibody or antibody against OR10R2 could matter depends on whether native OR10R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10R2 is annotated at the cell surface, where native OR10R2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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