Seroatlas · Human Serome Atlas

OR10K2

Olfactory receptor 10K2

Also known as: O10K2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IF99
Gene: OR10K2
Ensembl: ENSG00000180708
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q6IF99|OR10K2
     1  MERVNETVVR EVIFLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV LDRALHIPMY
    61  FFLAILSCSE ICYTFIIVPK MLVDLLSQKK TISFLGCAIQ MFSFLFLGCS HSFLLAVMGY
   121  DRYIAICNPL RYSVLMGHGV CMGLVAAACA CGFTVAQIIT SLVFHLPFYS SNQLHHFFCD
   181  IAPVLKLASH HNHFSQIVIF MLCTLVLAIP LLLILVSYVH ILSAILQFPS TLGRCKAFST
   241  CVSHLIIVTV HYGCASFIYL RPQSNYSSSQ DALISVSYTI ITPLFNPMIY SLRNKEFKSA
   301  LCKIVRRTIS LL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10K2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

suprabasal keratinocytes: 0.3 nCPM
cdc: 0.1 nCPM
colonocytes: 0.1 nCPM
neutrophils: 0.1 nCPM
ovarian stromal cells: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
cerebral cortex: 0.6 nTPM
medulla oblongata: 0.6 nTPM
midbrain: 0.6 nTPM
amygdala: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.85
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10K2 as an antibody target. Whether an autoantibody or antibody against OR10K2 could matter depends on whether native OR10K2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10K2 is annotated at the cell surface, where native OR10K2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10K2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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