Seroatlas · Human Serome Atlas

OR10K1

Olfactory receptor 10K1

Also known as: O10K1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGX5
Gene: OR10K1
Ensembl: ENSG00000173285
Chromosome: 1
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGX5|OR10K1
     1  MEQVNKTVVR EFVVLGFSSL ARLQQLLFVI FLLLYLFTLG TNAIIISTIV LDRALHTPMY
    61  FFLAILSCSE ICYTFVIVPK MLVDLLSQKK TISFLGCAIQ MFSFLFFGSS HSFLLAAMGY
   121  DRYMAICNPL RYSVLMGHGV CMGLMAAACA CGFTVSLVTT SLVFHLPFHS SNQLHHFFCD
   181  ISPVLKLASQ HSGFSQLVIF MLGVFALVIP LLLILVSYIR IISAILKIPS SVGRYKTFST
   241  CASHLIVVTV HYSCASFIYL RPKTNYTSSQ DTLISVSYTI LTPLFNPMIY SLRNKEFKSA
   301  LRRTIGQTFY PLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10K1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

esophagus: 0.8 nTPM
retina: 0.7 nTPM
bone marrow: 0.5 nTPM
skeletal muscle: 0.5 nTPM
tonsil: 0.3 nTPM
appendix: 0.2 nTPM

Single-cell type

kupffer cells: 1 nCPM
neutrophils: 0.3 nCPM
pericytes: 0.3 nCPM
bergmann glia: 0.1 nCPM
cardiomyocytes: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
gdT-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

white matter: 24 nTPM
cerebellum: 21 nTPM
cerebral cortex: 20 nTPM
thalamus: 18 nTPM
pons: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0.31
gnomAD missense Z: -0.68
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10K1 as an antibody target. Whether an autoantibody or antibody against OR10K1 could matter depends on whether native OR10K1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10K1 is annotated at the cell surface, where native OR10K1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10K1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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