Seroatlas · Human Serome Atlas

OR10J3

Olfactory receptor 10J3

Also known as: O10J3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JRS4
Gene: OR10J3
Canonical length: 329 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR10J3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q5JRS4|OR10J3
     1  MPKLNSTFVT EFLFEGFSSF RRQHKLVFFV VFLTLYLLTL SGNVIIMTII RLDHHLHTPM
    61  YFFLCMLSIS ETCYTVAIIP HMLSGLLNPH QPIATQSCAT QLFFYLTFGI NNCFLLTVMG
   121  YDRYVAICNP LRYSVIMGKR ACIQLASGSL GIGLGMAIVQ VTSVFGLPFC DAFVISHFFC
   181  DVRHLLKLAC TDTTVNEIIN FVVSVCVLVL PMGLVFISYV LIISTILKIA SAEGQKKAFA
   241  TCASHLTVVI IHYGCASIIY LKPKSQSSLG QDRLISVTYT HHSPTEPCCV QPEEQGGQRC
   301  SAQSRGAKNS VSLMKRGCEG FSFAFINMY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10J3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

placenta: 0.3 nTPM
retina: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -1.33

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10J3 as an antibody target. Whether an autoantibody or antibody against OR10J3 could matter depends on whether native OR10J3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10J3 is annotated at the cell surface, where native OR10J3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10J3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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