Seroatlas · Human Serome Atlas

OR10H5

Olfactory receptor 10H5

Also known as: O10H5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGA6
Gene: OR10H5
Ensembl: ENSG00000172519
Chromosome: 19
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NGA6|OR10H5
     1  MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHMPMY
    61  LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY
   121  DRYVAICHPL RYNVLMSLRG CTCRVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH
   181  VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS
   241  TCASHLTVVV VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV
   301  AMKKTCFTKL FPQNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10H5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 0.6 nTPM
bone marrow: 0.5 nTPM
skin: 0.3 nTPM
epididymis: 0.2 nTPM
retina: 0.2 nTPM
adrenal gland: 0.1 nTPM

Single-cell type

epicardial cells: 2.3 nCPM
gastric chief cells: 1.1 nCPM
mucous neck cells: 0.8 nCPM
pancreatic islet cells: 0.7 nCPM
foveolar cells: 0.6 nCPM
early primary spermatocytes: 0.3 nCPM

Immune cell

basophil: 1.2 nTPM
neutrophil: 0.8 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebellum: 6.1 nTPM
cerebral cortex: 6.1 nTPM
amygdala: 5.9 nTPM
white matter: 5.7 nTPM
hippocampal formation: 5.4 nTPM
thalamus: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.07
gnomAD missense Z: -0.5
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10H5 as an antibody target. Whether an autoantibody or antibody against OR10H5 could matter depends on whether native OR10H5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10H5 is annotated at the cell surface, where native OR10H5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10H5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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