Seroatlas · Human Serome Atlas

OR10G8

Olfactory receptor 10G8

Also known as: O10G8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGN5
Gene: OR10G8
Ensembl: ENSG00000234560
Chromosome: 11
Canonical length: 311 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q8NGN5|OR10G8
     1  MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD SHLHTTMYYF
    61  LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL YFFHFLGGTE CFLYRVMSCD
   121  RYLAISYPLR YTSMMTGRSC TLLATSTWLS GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA
   181  PPILKLACAD TSAIETVIFV TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC
   241  ASHCIVVLCF FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK
   301  LKDKVAHSQS K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10G8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

pancreatic acinar cells: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
basal ganglia: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0.02
gnomAD missense Z: -1.01
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10G8 as an antibody target. Whether an autoantibody or antibody against OR10G8 could matter depends on whether native OR10G8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10G8 is annotated at the cell surface, where native OR10G8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10G8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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