Seroatlas · Human Serome Atlas

OR10G6

Olfactory receptor 10G6

Also known as: O10G6_HUMAN, OR10G6P, OR10G6Q

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH81
Gene: OR10G6
Ensembl: ENSG00000198674
Chromosome: 11
Canonical length: 332 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q8NH81|OR10G6
     1  MLEGVEHLLL LLLLTDVNSK ELQSGNQTSV SHFILVGLHH PPQLGAPLFL AFLVIYLLTV
    61  SGNGLIILTV LVDIRLHRPM CLFLCHLSFL DMTISCAIVP KMLAGFLLGS RIISFGGCVI
   121  QLFSFHFLGC TECFLYTLMA YDRFLAICKP LHYATIMTHR VCNSLALGTW LGGTIHSLFQ
   181  TSFVFRLPFC GPNRVDYIFC DIPAMLRLAC ADTAINELVT FADIGFLALT CFMLILTSYG
   241  YIVAAILRIP SADGRRNAFS TCAAHLTVVI VYYVPCTFIY LRPCSQEPLD GVVAVFYTVI
   301  TPLLNSIIYT LCNKEMKAAL QRLGGHKEVQ PH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10G6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

pancreas: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 0.4 nCPM
pancreatic acinar cells: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
hypothalamus: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
thalamus: 0.1 nTPM

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10G6 as an antibody target. Whether an autoantibody or antibody against OR10G6 could matter depends on whether native OR10G6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10G6 is annotated at the cell surface, where native OR10G6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10G6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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