Seroatlas · Human Serome Atlas

OR10D3

Olfactory receptor 10D3

Also known as: HTPCRX09, O10D3_HUMAN, OR10D3P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH80
Gene: OR10D3
Ensembl: ENSG00000197309
Chromosome: 11
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NH80|OR10D3
     1  MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM SSARLHTPMY
    61  FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ LFFFHFLGSI ECFLFTVMAY
   121  DRFTAICYPL RYTVIMNPRI CVALAVGTWL LGCIHSSILT SLTFTLPYCG PNEVDHFFCD
   181  IPALLPLACA DTSLAQRVSF TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST
   241  CSAHLIAILC AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
   301  TILHRTGHVP ES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

testis: 0.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early primary spermatocytes: 2.3 nCPM
undifferentiated spermatogonia: 2.1 nCPM
differentiating spermatogonia: 1.4 nCPM
other brain neurons: 1.2 nCPM
granulosa cells: 0.8 nCPM
extravillous trophoblasts: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
hypothalamus: 0.4 nTPM
basal ganglia: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0.02
gnomAD missense Z: 0.96

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10D3 as an antibody target. Whether an autoantibody or antibody against OR10D3 could matter depends on whether native OR10D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10D3 is annotated at the cell surface, where native OR10D3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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