Seroatlas · Human Serome Atlas

OR10AD1

Olfactory receptor 10AD1

Also known as: O10AD_HUMAN, OR10AD1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGE0
Gene: OR10AD1
Ensembl: ENSG00000172640
Chromosome: 12
Canonical length: 317 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q8NGE0|OR10AD1
     1  MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS WTDPKLNSPM
    61  YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT QMYFVFCVGV AECILLAFMA
   121  YDRYVAICYP LNYVPIISQK VCVRLVGTAW FFGLINGIFL EYISFREPFR RDNHIESFFC
   181  EAPIVIGLSC GDPQFSLWAI FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS
   241  TCASHLTVVI FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
   301  AMVRALGRTR LAQPQSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10AD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

retina: 2.3 nTPM
pituitary gland: 0.8 nTPM
testis: 0.8 nTPM
cerebellum: 0.5 nTPM
adrenal gland: 0.4 nTPM
appendix: 0.3 nTPM

Single-cell type

adipocytes: 0.8 nCPM
cardiomyocytes: 0.5 nCPM
early spermatids: 0.4 nCPM
papillary tip epithelial cells: 0.2 nCPM
fibroblasts: 0.1 nCPM
late spermatids: 0.1 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 6.1 nTPM
midbrain: 4 nTPM
hypothalamus: 3.7 nTPM
medulla oblongata: 3.7 nTPM
pons: 3.4 nTPM
thalamus: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0.01
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10AD1 as an antibody target. Whether an autoantibody or antibody against OR10AD1 could matter depends on whether native OR10AD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10AD1 is annotated at the cell surface, where native OR10AD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10AD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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