Seroatlas · Human Serome Atlas

OR10AC1

Olfactory receptor 10AC1

Also known as: O10AC_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH08
Gene: OR10AC1
Canonical length: 325 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR10AC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q8NH08|OR10AC1
     1  MDSPSNATVP CGFLLQGFSE FPHLRPVLFL LLLGVHLATL GGNLLILVAV ASMPSRQPML
    61  LFLCQLSAIE LCYTLVVVPR SLVDLSTPGH RRGSPISFLS CAFQMQMFVA LGGAECFLLA
   121  AMAYDRYVAI CHPLRYAAVV TPGLCARLAL ACCLRGLAVS VGLTVAIFHL PFCGSRLLLH
   181  FFCDITALLH LACTRSYADE LPLLGACLVL LLLPSVLILA SYGAIAAALR RLRCPKGRGK
   241  AASTCALHLA VTFLHYGCAT FMYVRPRASY SPRLDRTLAL VYTNVTPLLC PLIYSLRNRE
   301  ITAALSRVLG RRRPGQAPGG DLREL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR10AC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

thymus: 1.7 nTPM
parathyroid gland: 0.8 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM

Single-cell type

brain excitatory neurons: 0.4 nCPM
microglia: 0.4 nCPM
other brain neurons: 0.2 nCPM
brain inhibitory neurons: 0.1 nCPM
fibroblasts: 0.1 nCPM
monocytes: 0.1 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

cerebellum: 0.5 nTPM
cerebral cortex: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
choroid plexus: 0.3 nTPM
hippocampal formation: 0.3 nTPM

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR10AC1 as an antibody target. Whether an autoantibody or antibody against OR10AC1 could matter depends on whether native OR10AC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR10AC1 is annotated at the cell surface, where native OR10AC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR10AC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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