OR10A4
Olfactory receptor 10A4
Also known as: O10A4_HUMAN, OR10A4P
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H209
- Gene
- OR10A4
- Ensembl
- ENSG00000170782
- Chromosome
- 11
- Canonical length
- 315 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
315 residues, UniProt reviewed canonical sequence.
>Q9H209|OR10A4
1 MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT IADSALQSPM
61 YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT QMYFFFFFGA AECCLLATMA
121 YDRYVAICDP LHYPVIMGHI SCAQLAAASW FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC
181 DSPPVIALVC ADTSVFELEA LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS
241 TCSAHLLVVS LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA
301 ALKRLIHRTL GSQKLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR10A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- brain inhibitory neurons: 0.3 nCPM
- brain excitatory neurons: 0.2 nCPM
- other brain neurons: 0.2 nCPM
- renal collecting duct principal cells: 0.2 nCPM
- cardiomyocytes: 0.1 nCPM
- differentiating spermatogonia: 0.1 nCPM
Immune cell
- plasmacytoid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- basal ganglia: 1.9 nTPM
- cerebral cortex: 1.9 nTPM
- amygdala: 1.4 nTPM
- hippocampal formation: 1.4 nTPM
- hypothalamus: 1.3 nTPM
- medulla oblongata: 1.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.19
- DepMap mean gene effect
- -0.31
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR10A4 as an antibody target. Whether an autoantibody or antibody against OR10A4 could matter depends on whether native OR10A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR10A4 is annotated at the cell surface, where native OR10A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR10A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...