Seroatlas · Human Serome Atlas

OPRD1

Delta-type opioid receptor

Also known as: OPRD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41143
Gene
OPRD1
Ensembl
ENSG00000116329
Chromosome
1
Canonical length
372 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables G protein-coupled enkephalin receptor activity. Involved in several processes, including G protein-coupled opioid receptor signaling pathway; cellular response to hypoxia; and positive regulation of peptidyl-serine phosphorylation. Located in plasma membrane. Implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Biomarker of opioid abuse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>P41143|OPRD1
     1  MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI AITALYSAVC
    61  AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL
   121  CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG
   181  VPIMVMAVTR PRDGAVVCML QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL
   241  RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL
   301  HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE ATARERVTAC
   361  TPSDGPGGGA AA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OPRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
2.7 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 2.7 nTPM
  • basal ganglia: 1.4 nTPM
  • hippocampal formation: 0.9 nTPM
  • skeletal muscle: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • adrenal gland: 0.5 nTPM

Single-cell type

  • other brain neurons: 28 nCPM
  • adrenal medulla cells: 21 nCPM
  • brain inhibitory neurons: 18 nCPM
  • brain excitatory neurons: 17 nCPM
  • pancreatic islet cells: 9.3 nCPM
  • retinal bipolar cells: 8.8 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • neutrophil: 0.4 nTPM
  • NK-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • pons: 18 nTPM
  • cerebral cortex: 15 nTPM
  • hippocampal formation: 11 nTPM
  • basal ganglia: 10 nTPM
  • amygdala: 10 nTPM
  • white matter: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
1.58
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OPRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OPRD1 as an antibody target. Whether an autoantibody or antibody against OPRD1 could matter depends on whether native OPRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OPRD1 is annotated at the cell surface, where native OPRD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OPRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OPRD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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