Seroatlas · Human Serome Atlas

OPN5

Opsin-5

Also known as: dJ402H5.1, neuropsin, OPN5_HUMAN, TMEM13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6U736
Gene: OPN5
Ensembl: ENSG00000124818
Chromosome: 6
Canonical length: 354 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q6U736|OPN5
     1  MALNHTALPQ DERLPHYLRD GDPFASKLSW EADLVAGFYL TIIGILSTFG NGYVLYMSSR
    61  RKKKLRPAEI MTINLAVCDL GISVVGKPFT IISCFCHRWV FGWIGCRWYG WAGFFFGCGS
   121  LITMTAVSLD RYLKICYLSY GVWLKRKHAY ICLAAIWAYA SFWTTMPLVG LGDYVPEPFG
   181  TSCTLDWWLA QASVGGQVFI LNILFFCLLL PTAVIVFSYV KIIAKVKSSS KEVAHFDSRI
   241  HSSHVLEMKL TKVAMLICAG FLIAWIPYAV VSVWSAFGRP DSIPIQLSVV PTLLAKSAAM
   301  YNPIIYQVID YKFACCQTGG LKATKKKSLE GFRLHTVTTV RKSSAVLEIH EEWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OPN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

testis: 2.4 nTPM
heart muscle: 0.4 nTPM
skeletal muscle: 0.1 nTPM
tongue: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 50 nCPM
late spermatids: 49 nCPM
early spermatids: 33 nCPM
myosatellite cells: 31 nCPM
early primary spermatocytes: 8.4 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.5 nTPM
cerebral cortex: 0.4 nTPM
pons: 0.4 nTPM
basal ganglia: 0.3 nTPM
hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.86
gnomAD missense Z: 1.78
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OPN5 as an antibody target. Whether an autoantibody or antibody against OPN5 could matter depends on whether native OPN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OPN5 is annotated at the cell surface, where native OPN5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OPN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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