OPN3

Protein identityUniProt · HPA

UniProt accession

Q9H1Y3

Gene

OPN3

Ensembl

ENSG00000054277

Chromosome

1

Canonical length

402 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q9H1Y3|OPN3
     1  MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS IGLLGVGNNL
    61  LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV SCLRNGWVWD TVGCVWDGFS
   121  GSLFGIVSIA TLTVLAYERY IRVVHARVIN FSWAWRAITY IWLYSLAWAG APLLGWNRYI
   181  LDVHGLGCTV DWKSKDANDS SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT
   241  IQVIKILKYE KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS
   301  NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI VMSQKDGDRP
   361  KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OPN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0

gnomAD missense Z

1.1

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• cellular response to light stimulus
• cellular response to UV-A
• G protein-coupled receptor signaling pathway
• keratinocyte differentiation
• negative regulation of apoptotic process
• negative regulation of melanin biosynthetic process
• phototransduction
• positive regulation of cellular respiration
• positive regulation of D-glucose import
• positive regulation of eating behavior
• positive regulation of melanin biosynthetic process
• regulation of circadian rhythm
• response to blue light
• detection of light stimulus

Molecular functions

• 11-cis retinal binding
• all-trans retinal binding
• G protein-coupled photoreceptor activity
• G protein-coupled receptor activity
• photoreceptor activity

Cellular components

• cytoplasm
• membrane
• photoreceptor outer segment
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• Visual pigments (opsins) retinal binding site
• G-protein coupled receptor opsins
• 7 transmembrane receptor (rhodopsin family)

KeywordsUniProt

• Cell membrane
• Chromophore
• Cytoplasm
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lipoprotein
• Membrane
• Palmitate
• Photoreceptor protein
• Receptor
• Retinal protein
• Sensory transduction
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of OPN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MC1R