Seroatlas · Human Serome Atlas

OPN1SW

Short-wave-sensitive opsin 1

Also known as: BCP, BOP, CBT, OPSB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P03999
Gene
OPN1SW
Ensembl
ENSG00000128617
Chromosome
7
Canonical length
345 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>P03999|OPN1SW
     1  MSEEEFYLFK NISSVGPWDG PQYHIAPVWA FYLQAAFMGT VFLIGFPLNA MVLVATLRYK
    61  KLRQPLNYIL VNVSFGGFLL CIFSVFPVFV ASCNGYFVFG RHVCALEGFL GTVAGLVTGW
   121  SLAFLAFERY IVICKPFGNF RFSSKHALTV VLATWTIGIG VSIPPFFGWS RFIPEGLQCS
   181  CGPDWYTVGT KYRSESYTWF LFIFCFIVPL SLICFSYTQL LRALKAVAAQ QQESATTQKA
   241  EREVSRMVVV MVGSFCVCYV PYAAFAMYMV NNRNHGLDLR LVTIPSFFSK SACIYNPIIY
   301  CFMNKQFQAC IMKMVCGKAM TDESDTCSSQ KTEVSTVSST QVGPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OPN1SW can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • retina: 38 nTPM
  • testis: 0.2 nTPM
  • adipose tissue: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • endometrium: 0.1 nTPM
  • hypothalamus: 0.1 nTPM

Single-cell type

  • cone photoreceptor cells: 182 nCPM
  • epicardial cells: 21 nCPM
  • fibro-adipogenic progenitors: 6.5 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • cardiomyocytes: 6.2 nCPM
  • adipocytes: 4.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.1 nTPM
  • white matter: 1.1 nTPM
  • choroid plexus: 1 nTPM
  • cerebral cortex: 0.9 nTPM
  • hippocampal formation: 0.8 nTPM
  • basal ganglia: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OPN1SW.

Disease | AllUniProt

Conditions OPN1SW is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0.02
gnomAD missense Z
0.01
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OPN1SW as an antibody target. Whether an autoantibody or antibody against OPN1SW could matter depends on whether native OPN1SW is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OPN1SW is annotated at the cell surface, where native OPN1SW is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OPN1SW as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OPN1SW. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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