Seroatlas · Human Serome Atlas

OPALIN

Opalin

Also known as: HTMP10, OPALI_HUMAN, TMEM10, TMP10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PE5
Gene
OPALIN
Ensembl
ENSG00000197430
Chromosome
10
Canonical length
141 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in regulation of oligodendrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>Q96PE5|OPALIN
     1  MSFSLNFTLP ANTTSSPVTG GKETDCGPSL GLAAGIPLLV ATALLVALLF TLIHRRRSSI
    61  EAMEESDRPC EISEIDDNPK ISENPRRSPT HEKNTMGAQE AHIYVKTVAG SEEPVHDRYR
   121  PTIEMERRRG LWWLVPRLSL E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OPALIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 139 nTPM
  • hippocampal formation: 128 nTPM
  • amygdala: 116 nTPM
  • midbrain: 77 nTPM
  • spinal cord: 65 nTPM
  • hypothalamus: 54 nTPM

Single-cell type

  • oligodendrocytes: 514 nCPM
  • thymocytes: 6.8 nCPM
  • microglia: 6.6 nCPM
  • astrocytes: 5.2 nCPM
  • oligodendrocyte progenitor cells: 5.1 nCPM
  • oocytes: 4.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 220 nTPM
  • basal ganglia: 191 nTPM
  • cerebral cortex: 154 nTPM
  • amygdala: 145 nTPM
  • midbrain: 129 nTPM
  • hippocampal formation: 128 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Opalin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OPALIN as an antibody target. Whether an autoantibody or antibody against OPALIN could matter depends on whether native OPALIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OPALIN is annotated at the cell surface, where native OPALIN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OPALIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OPALIN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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