Seroatlas · Human Serome Atlas

OOSP4B

Oocyte-secreted protein 4B

Also known as: OSP4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8Y4Y8
Gene
OOSP4B
Ensembl
ENSG00000255393
Chromosome
11
Canonical length
160 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>A0A2R8Y4Y8|OOSP4B
     1  MKTSVLLAIT AMCSDDWLLV RMKIRPFDKN TDIRIGDIHL RDNCPVTRLL SFNYAFSYPV
    61  TSCGIKKIMF QTNDDAILSE ISYKPRLHTT YEFPVVCFVK RLKFPSVMHF GMSGFDAHTL
   121  KEIPQKTKGQ ESPTPTQSKT WTLNFNSVNK EQLSKKSLYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OOSP4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • oocytes: 23 nCPM
  • proximal tubule cells: 0.6 nCPM
  • undifferentiated spermatogonia: 0.6 nCPM
  • papillary tip epithelial cells: 0.4 nCPM
  • distal convoluted tubule cells: 0.3 nCPM
  • podocytes: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OOSP4B as an antibody target. Whether an autoantibody or antibody against OOSP4B could matter depends on whether native OOSP4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OOSP4B is annotated as secreted, so native OOSP4B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OOSP4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OOSP4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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