Seroatlas · Human Serome Atlas

OOSP4A

Oocyte-secreted protein 4A

Also known as: OSP4A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8YFL7
Gene
OOSP4A
Ensembl
ENSG00000285010
Chromosome
11
Canonical length
184 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>A0A2R8YFL7|OOSP4A
     1  MKISCVLGKL LMLFELIHGL QDLSITCSES WLQVKLRRTP LLNDLQPLQN ELSLGIGCPV
    61  NMVEVDFFGF LYLLTFCGIR VSEHGVGILI ESLIVYEPTN FDFNLHIPVS CYVQRRFPII
   121  LVMRGRENDS RRECRRSVGQ HRSLSHELED LEIRPRVSYV NSVPLLSYLI VSLPKCKNKA
   181  VHSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OOSP4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 0.1 nTPM
  • kidney: 0.1 nTPM
  • ovary: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • proximal tubule cells: 0.4 nCPM
  • brain excitatory neurons: 0.2 nCPM
  • papillary tip epithelial cells: 0.2 nCPM
  • brain inhibitory neurons: 0.1 nCPM
  • distal convoluted tubule cells: 0.1 nCPM
  • loop of henle epithelial cells: 0.1 nCPM

Immune cell

  • basophil: 7.5 nTPM
  • memory B-cell: 0.3 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • white matter: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • thalamus: 0.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OOSP4A as an antibody target. Whether an autoantibody or antibody against OOSP4A could matter depends on whether native OOSP4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OOSP4A is annotated as secreted, so native OOSP4A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OOSP4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OOSP4A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...