Seroatlas · Human Serome Atlas

OOSP3

Oocyte-secreted protein 3

Also known as: OOSP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8YFM6
Gene
OOSP3
Ensembl
ENSG00000285231
Chromosome
11
Canonical length
193 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>A0A2R8YFM6|OOSP3
     1  MKDFVRLQSS FLLCTILTLS EQESVSVGCT SSMFWVVAEP TLLGQDHILH SDEASLGTGC
    61  PVTNVTAKGY EFNYPATQCG IQKEVFSYVT VFYSALHCNI MHKGVTGKIP LMCIVYGSSL
   121  DTTSSTIHNN LTEFQNDPPA TNSYSPWNLT NASLFGLTRI PYFQNSSVEA SHQSLLLNMS
   181  HPLVHESANV AIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OOSP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
0.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.3 nTPM
  • bone marrow: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • duodenum: 0.1 nTPM
  • salivary gland: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM

Single-cell type

  • epididymal efferent duct ciliated cells: 39 nCPM
  • neutrophils: 10 nCPM
  • sertoli cells: 8.4 nCPM
  • proximal tubule cells: 5.2 nCPM
  • parietal cells: 3.5 nCPM
  • distal convoluted tubule cells: 2.7 nCPM

Immune cell

  • basophil: 5.4 nTPM
  • eosinophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.1 nTPM
  • cerebral cortex: 1 nTPM
  • thalamus: 0.8 nTPM
  • medulla oblongata: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OOSP3 as an antibody target. Whether an autoantibody or antibody against OOSP3 could matter depends on whether native OOSP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OOSP3 is annotated as secreted, so native OOSP3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OOSP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OOSP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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