Seroatlas · Human Serome Atlas

OOSP2

Oocyte-secreted protein 2

Also known as: FLJ36198, OOSP2_HUMAN, OOSP2A, PLAC1L, TMEM122

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86WS3
Gene
OOSP2
Ensembl
ENSG00000149507
Chromosome
11
Canonical length
158 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Involved in oocyte maturation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

158 residues, UniProt reviewed canonical sequence.

>Q86WS3|OOSP2
     1  MALEVLMLLA VLIWTGAENL HVKISCSLDW LMVSVIPVAE SRNLYIFADE LHLGMGCPAN
    61  RIHTYVYEFI YLVRDCGIRT RVVSEETLLF QTELYFTPRN IDHDPQEIHL ECSTSRKSVW
   121  LTPVSTENEI KLDPSPFIAD FQTTAEELGL LSSSPNLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OOSP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • ovary: 0.9 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • oocytes: 175 nCPM
  • sertoli cells: 13 nCPM
  • late spermatids: 2.5 nCPM
  • late primary spermatocytes: 1 nCPM
  • early spermatids: 0.9 nCPM
  • ovarian stromal cells: 0.3 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.33
gnomAD pLI
0.03
gnomAD missense Z
0.46
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OOSP2 as an antibody target. Whether an autoantibody or antibody against OOSP2 could matter depends on whether native OOSP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OOSP2 is annotated as secreted, so native OOSP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OOSP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OOSP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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