Seroatlas · Human Serome Atlas

OOSP1

Putative oocyte-secreted protein 1 homolog

Also known as: OOSP1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MZH6
Gene
OOSP1
Canonical length
123 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for OOSP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>A8MZH6|OOSP1
     1  MKTILGFKGL FYLHSLIWTC AGDWSAIQVH CTQFWFFARI KPTIFYNLYV NPDEVFLGDG
    61  CHVTHVLPNV YYEFFYHPHD CGIVTQPLQE VLLLKTKIRY ISRDSTVRSE MPLSCVVHKQ
   121  KCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OOSP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • proximal tubule cells: 4.7 nCPM
  • brain excitatory neurons: 1.2 nCPM
  • late spermatids: 1.2 nCPM
  • distal convoluted tubule cells: 1 nCPM
  • other brain neurons: 1 nCPM
  • brain inhibitory neurons: 0.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.5 nTPM
  • white matter: 1.4 nTPM
  • cerebellum: 1.2 nTPM
  • hippocampal formation: 1.2 nTPM
  • basal ganglia: 1.1 nTPM
  • pons: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0.38
gnomAD missense Z
1.22

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OOSP1 as an antibody target. Whether an autoantibody or antibody against OOSP1 could matter depends on whether native OOSP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OOSP1 is annotated as secreted, so native OOSP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OOSP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OOSP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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