Seroatlas · Human Serome Atlas

ONECUT2

One cut domain family member 2

Also known as: OC-2, ONEC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95948
Gene: ONECUT2
Ensembl: ENSG00000119547
Chromosome: 18
Canonical length: 504 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Actin filaments

OverviewNCBI Gene

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>O95948|ONECUT2
     1  MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG GGGGPGHEQE
    61  LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA ASRSAMVTSM ASILDGGDYR
   121  PELSIPLHHA MSMSCDSSPP GMGMSNTYTT LTPLQPLPPI STVSDKFHHP HPHHHPHHHH
   181  HHHHQRLSGN VSGSFTLMRD ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH
   241  NAQQSLPNYG PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH
   301  TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS IPQAIFAQRV
   361  LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF QRMSALRLAA CKRKEQEPNK
   421  DRNNSQKKSR LVFTDLQRRT LFAIFKENKR PSKEMQITIS QQLGLELTTV SNFFMNARRR
   481  SLEKWQDDLS TGGSSSTSST CTKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ONECUT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

duodenum: 9.5 nTPM
gallbladder: 9.5 nTPM
liver: 7.9 nTPM
retina: 5 nTPM
basal ganglia: 3.1 nTPM
pancreas: 2.1 nTPM

Single-cell type

retinal horizontal cells: 581 nCPM
cholangiocytes: 165 nCPM
gastric progenitor cells: 163 nCPM
pancreatic duct cells: 157 nCPM
brain inhibitory neurons: 102 nCPM
hepatocytes: 66 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 20 nTPM
hypothalamus: 9.7 nTPM
cerebral cortex: 6.2 nTPM
thalamus: 3 nTPM
cerebellum: 2.5 nTPM
pons: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.91
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ONECUT2 as an antibody target. Whether an autoantibody or antibody against ONECUT2 could matter depends on whether native ONECUT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ONECUT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ONECUT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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