Seroatlas · Human Serome Atlas

ONECUT1

Hepatocyte nuclear factor 6

Also known as: HNF-6, HNF6, HNF6_HUMAN, HNF6A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBC0
Gene
ONECUT1
Ensembl
ENSG00000169856
Chromosome
15
Canonical length
465 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q9UBC0|ONECUT1
     1  MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP RSMGMASLLD
    61  GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD
   121  KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS
   181  PLSSSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG
   241  MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
   301  ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ
   361  RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ
   421  QLGLELSTVS NFFMNARRRS LDKWQDEGSS NSGNSSSSSS TCTKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ONECUT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 14 nTPM
  • liver: 12 nTPM
  • gallbladder: 5.4 nTPM
  • retina: 3.8 nTPM
  • testis: 1.1 nTPM
  • bone marrow: 0.4 nTPM

Single-cell type

  • retinal horizontal cells: 1,042 nCPM
  • cholangiocytes: 278 nCPM
  • pancreatic duct cells: 174 nCPM
  • pancreatic acinar cells: 119 nCPM
  • hepatocytes: 116 nCPM
  • retinal ganglion cells: 100 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 5.1 nTPM
  • hypothalamus: 4.7 nTPM
  • medulla oblongata: 4.3 nTPM
  • pons: 4 nTPM
  • amygdala: 2.2 nTPM
  • basal ganglia: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.52
gnomAD missense Z
0.52
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ONECUT1 as an antibody target. Whether an autoantibody or antibody against ONECUT1 could matter depends on whether native ONECUT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ONECUT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ONECUT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ONECUT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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