Seroatlas · Human Serome Atlas

OMA1

Metalloendopeptidase OMA1, mitochondrial

Also known as: FLJ33782, MPRP-1, OMA1_HUMAN, YKR087C, ZMPOMA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96E52
Gene
OMA1
Ensembl
ENSG00000162600
Chromosome
1
Canonical length
524 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Mitochondria
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables metalloendopeptidase activity. Involved in several processes, including HRI-mediated signaling; proteolysis; and regulation of mitochondrion organization. Located in mitochondrial inner membrane. Is active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q96E52|OMA1
     1  MSFICGLQSA ARNHVFFRFN SLSNWRKCNT LASTSRGCHQ VQVNHIVNKY QGLGVNQCDR
    61  WSFLPGNFHF YSTFNNKRTG GLSSTKSKEI WRITSKCTVW NDAFSRQLLI KEVTAVPSLS
   121  VLHPLSPASI RAIRNFHTSP RFQAAPVPLL LMILKPVQKL FAIIVGRGIR KWWQALPPNK
   181  KEVVKENIRK NKWKLFLGLS SFGLLFVVFY FTHLEVSPIT GRSKLLLLGK EQFRLLSELE
   241  YEAWMEEFKN DMLTEKDARY LAVKEVLCHL IECNKDVPGI SQINWVIHVV DSPIINAFVL
   301  PNGQMFVFTG FLNSVTDIHQ LSFLLGHEIA HAVLGHAAEK AGMVHLLDFL GMIFLTMIWA
   361  ICPRDSLALL CQWIQSKLQE YMFNRPYSRK LEAEADKIGL LLAAKACADI RASSVFWQQM
   421  EFVDSLHGQP KMPEWLSTHP SHGNRVEYLD RLIPQALKIR EMCNCPPLSN PDPRLLFKLS
   481  TKHFLEESEK EDLNITKKQK MDTLPIQKQE QIPLTYIVEK RTGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OMA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • liver: 29 nTPM
  • tongue: 28 nTPM
  • kidney: 27 nTPM
  • skeletal muscle: 27 nTPM
  • lymph node: 22 nTPM
  • tonsil: 20 nTPM

Single-cell type

  • parietal cells: 16 nCPM
  • late spermatids: 14 nCPM
  • tuft cells: 12 nCPM
  • fallopian tube ciliated cells: 9.6 nCPM
  • lacrimal acinar cells: 9.1 nCPM
  • conjunctival goblet cells: 7.8 nCPM

Immune cell

  • memory B-cell: 36 nTPM
  • non-classical monocyte: 35 nTPM
  • naive B-cell: 35 nTPM
  • naive CD4 T-cell: 34 nTPM
  • eosinophil: 32 nTPM
  • naive CD8 T-cell: 31 nTPM

Brain region

  • white matter: 59 nTPM
  • cerebellum: 52 nTPM
  • basal ganglia: 51 nTPM
  • pons: 49 nTPM
  • hypothalamus: 45 nTPM
  • medulla oblongata: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OMA1 as an antibody target. Whether an autoantibody or antibody against OMA1 could matter depends on whether native OMA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OMA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OMA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OMA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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