OLIG3

Protein identityUniProt · HPA

UniProt accession

Q7RTU3

Gene

OLIG3

Ensembl

ENSG00000177468

Chromosome

6

Canonical length

272 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q7RTU3|OLIG3
     1  MNSDSSSVSS RASSPDMDEM YLRDHHHRHH HHQESRLNSV SSTQGDMMQK MPGESLSRAG
    61  AKAAGESSKY KIKKQLSEQD LQQLRLKING RERKRMHDLN LAMDGLREVM PYAHGPSVRK
   121  LSKIATLLLA RNYILMLTSS LEEMKRLVGE IYGGHHSAFH CGTVGHSAGH PAHAANSVHP
   181  VHPILGGALS SGNASSPLSA ASLPAIGTIR PPHSLLKAPS TPPALQLGSG FQHWAGLPCP
   241  CTICQMPPPP HLSALSTANM ARLSAESKDL LK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLIG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

0 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.51

gnomAD pLI

0.83

gnomAD missense Z

-0.25

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon development
• negative regulation of transcription by RNA polymerase II
• positive regulation of transcription by RNA polymerase II
• sensory organ development
• spinal cord motor neuron cell fate specification
• spinal cord motor neuron migration

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• E-box binding
• protein dimerization activity
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Myc-type, basic helix-loop-helix (bHLH) domain
• Helix-loop-helix DNA-binding domain superfamily
• Basic helix-loop-helix transcription factors
• Helix-loop-helix DNA-binding domain
• Oligodendrocyte transcription factor 3, basic helix-loop-helix domain

KeywordsUniProt

• Coiled coil
• DNA-binding
• Nucleus
• Transcription
• Transcription regulation