Seroatlas · Human Serome Atlas

OLFML3

Olfactomedin-like protein 3

Also known as: HNOEL-iso, OLF44, OLFL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRN5
Gene: OLFML3
Ensembl: ENSG00000116774
Chromosome: 1
Canonical length: 406 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q9NRN5|OLFML3
     1  MGPSTPLLIL FLLSWSGPLQ GQQHHLVEYM ERRLAALEER LAQCQDQSSR HAAELRDFKN
    61  KMLPLLEVAE KEREALRTEA DTISGRVDRL EREVDYLETQ NPALPCVEFD EKVTGGPGTK
   121  GKGRRNEKYD MVTDCGYTIS QVRSMKILKR FGGPAGLWTK DPLGQTEKIY VLDGTQNDTA
   181  FVFPRLRDFT LAMAARKASR VRVPFPWVGT GQLVYGGFLY FARRPPGRPG GGGEMENTLQ
   241  LIKFHLANRT VVDSSVFPAE GLIPPYGLTA DTYIDLAADE EGLWAVYATR EDDRHLCLAK
   301  LDPQTLDTEQ QWDTPCPREN AEAAFVICGT LYVVYNTRPA SRARIQCSFD ASGTLTPERA
   361  ALPYFPRRYG AHASLRYNPR ERQLYAWDDG YQIVYKLEMR KKEEEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFML3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 239 nTPM

Expression across tissuesHPA

Tissue

ovary: 239 nTPM
cervix: 160 nTPM
endometrium: 121 nTPM
placenta: 105 nTPM
vagina: 98 nTPM
fallopian tube: 95 nTPM

Single-cell type

hepatic stellate cells: 665 nCPM
decidual stromal cells: 467 nCPM
fibroblasts: 262 nCPM
ovarian stromal cells: 171 nCPM
endometrial stromal cells: 102 nCPM
smooth muscle cells: 70 nCPM

Immune cell

myeloid DC: 2.1 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 18 nTPM
medulla oblongata: 15 nTPM
thalamus: 14 nTPM
spinal cord: 14 nTPM
pons: 11 nTPM
choroid plexus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFML3 as an antibody target. Whether an autoantibody or antibody against OLFML3 could matter depends on whether native OLFML3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFML3 is annotated as secreted, so native OLFML3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFML3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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