Seroatlas · Human Serome Atlas

OLFML2B

Olfactomedin-like protein 2B

Also known as: DKFZP586L151, OLM2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68BL8
Gene: OLFML2B
Ensembl: ENSG00000162745
Chromosome: 1
Canonical length: 750 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted - unknown location
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

750 residues, UniProt reviewed canonical sequence.

>Q68BL8|OLFML2B
     1  MAKPRLLVLY FALIVVPAWV SSIVLTGTSE PPDAQTVAPA EDETLQNEAD NQENVLSQLL
    61  GDYDKVKAMS EGSDCQCKCV VRPLGRDACQ RINAGASRKE DFYTVETITS GSSCKCACVA
   121  PPSALNPCEG DFRLQKLREA DSQDLKLSTI IDMLEGAFYG LDLLKLHSVT TKLVGRVDKL
   181  EEEVSKNLTK ENEQIKEDME EIRTEMNKRG KENCSENILD SMPDIRSALQ RDAAAAYAHP
   241  EYEERFLQEE TVSQQINSIE LLQTRPLALP EVVKSQRPLQ RQVHLRGRPA SQPTVIRGIT
   301  YYKAKVSEEE NDIEEQQDEF FSGDNGVDLL IEDQLLRHNG LMTSVTRRPA ATRQGHSTAV
   361  TSDLNARTAP WSSALPQPST SDPSIANHAS VGPTLQTTSV SPDPTRESVL QPSPQVPATT
   421  VAHTATQQPA APAPPAVSPR EALMEAMHTV PVPPTTVRTD SLGKDAPAGW GTTPASPTLS
   481  PEEEDDIRNV IGRCKDTLST ITGPTTQNTY GRNEGAWMKD PLAKDERIYV TNYYYGNTLV
   541  EFRNLENFKQ GRWSNSYKLP YSWIGTGHVV YNGAFYYNRA FTRNIIKYDL KQRYVAAWAM
   601  LHDVAYEEAT PWRWQGHSDV DFAVDENGLW LIYPALDDEG FSQEVIVLSK LNAADLSTQK
   661  ETTWRTGLRR NFYGNCFVIC GVLYAVDSYN QRNANISYAF DTHTNTQIVP RLLFENEYSY
   721  TTQIDYNPKD RLLYAWDNGH QVTYHVIFAY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFML2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

gallbladder: 45 nTPM
blood vessel: 39 nTPM
placenta: 38 nTPM
adipose tissue: 22 nTPM
smooth muscle: 21 nTPM
thyroid gland: 20 nTPM

Single-cell type

myosatellite cells: 175 nCPM
late primary spermatocytes: 143 nCPM
hofbauer cells: 76 nCPM
early spermatids: 67 nCPM
decidual stromal cells: 52 nCPM
macrophages: 50 nCPM

Immune cell

intermediate monocyte: 6.7 nTPM
non-classical monocyte: 5.5 nTPM
myeloid DC: 0.6 nTPM
classical monocyte: 0.4 nTPM
neutrophil: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

thalamus: 18 nTPM
cerebral cortex: 12 nTPM
choroid plexus: 8.8 nTPM
hippocampal formation: 7.6 nTPM
pons: 6.6 nTPM
basal ganglia: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFML2B as an antibody target. Whether an autoantibody or antibody against OLFML2B could matter depends on whether native OLFML2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFML2B is annotated as secreted, so native OLFML2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFML2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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