Seroatlas · Human Serome Atlas

OLFML2A

Olfactomedin-like protein 2A

Also known as: FLJ00237, OLM2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68BL7
Gene: OLFML2A
Ensembl: ENSG00000185585
Chromosome: 9
Canonical length: 652 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles
Secretome location: Secreted - unknown location
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable extracellular matrix binding activity and identical protein binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q68BL7|OLFML2A
     1  MAAAALPPRP LLLLPLVLLL SGRPTRADSK VFGDLDQVRM TSEGSDCRCK CIMRPLSKDA
    61  CSRVRSGRAR VEDFYTVETV SSGTDCRCSC TAPPSSLNPC ENEWKMEKLK KQAPELLKLQ
   121  SMVDLLEGTL YSMDLMKVHA YVHKVASQMN TLEESIKANL SRENEVVKDS VRHLSEQLRH
   181  YENHSAIMLG IKKELSRLGL QLLQKDAAAA PATPATGTGS KAQDTARGKG KDISKYGSVQ
   241  KSFADRGLPK PPKEKLLQVE KLRKESGKGS FLQPTAKPRA LAQQQAVIRG FTYYKAGKQE
   301  VTEAVADNTL QGTSWLEQLP PKVEGRSNSA EPNSAEQDEA EPRSSERVDL ASGTPTSIPA
   361  TTTTATTTPT PTTSLLPTEP PSGPEVSSQG REASCEGTLR AVDPPVRHHS YGRHEGAWMK
   421  DPAARDDRIY VTNYYYGNSL VEFRNLENFK QGRWSNMYKL PYNWIGTGHV VYQGAFYYNR
   481  AFTKNIIKYD LRQRFVASWA LLPDVVYEDT TPWKWRGHSD IDFAVDESGL WVIYPAVDDR
   541  DEAQPEVIVL SRLDPGDLSV HRETTWKTRL RRNSYGNCFL VCGILYAVDT YNQQEGQVAY
   601  AFDTHTGTDA RPQLPFLNEH AYTTQIDYNP KERVLYAWDN GHQLTYTLHF VV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFML2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

spleen: 31 nTPM
colon: 28 nTPM
cervix: 27 nTPM
endometrium: 23 nTPM
ovary: 19 nTPM
urinary bladder: 18 nTPM

Single-cell type

vascular smooth muscle cells: 62 nCPM
thymic myoid cells: 54 nCPM
schwann cells: 54 nCPM
lymphatic endothelial cells: 53 nCPM
smooth muscle cells: 31 nCPM
breast myoepithelial cells: 28 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.5 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

cerebral cortex: 9.8 nTPM
choroid plexus: 6.9 nTPM
basal ganglia: 6.3 nTPM
medulla oblongata: 6 nTPM
pons: 5.8 nTPM
thalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFML2A as an antibody target. Whether an autoantibody or antibody against OLFML2A could matter depends on whether native OLFML2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFML2A is annotated as secreted, so native OLFML2A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFML2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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