Seroatlas · Human Serome Atlas

OLFML1

Olfactomedin-like protein 1

Also known as: OLFL1_HUMAN, UNQ564

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWY5
Gene: OLFML1
Ensembl: ENSG00000183801
Chromosome: 11
Canonical length: 402 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q6UWY5|OLFML1
     1  MMVALRGASA LLVLFLAAFL PPPQCTQDPA MVHYIYQRFR VLEQGLEKCT QATRAYIQEF
    61  QEFSKNISVM LGRCQTYTSE YKSAVGNLAL RVERAQREID YIQYLREADE CIESEDKTLA
   121  EMLLQEAEEE KKIRTLLNAS CDNMLMGIKS LKIVKKMMDT HGSWMKDAVY NSPKVYLLIG
   181  SRNNTVWEFA NIRAFMEDNT KPAPRKQILT LSWQGTGQVI YKGFLFFHNQ ATSNEIIKYN
   241  LQKRTVEDRM LLPGGVGRAL VYQHSPSTYI DLAVDEHGLW AIHSGPGTHS HLVLTKIEPG
   301  TLGVEHSWDT PCRSQDAEAS FLLCGVLYVV YSTGGQGPHR ITCIYDPLGT ISEEDLPNLF
   361  FPKRPRSHSM IHYNPRDKQL YAWNEGNQII YKLQTKRKLP LK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLFML1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

ovary: 63 nTPM
cervix: 26 nTPM
gallbladder: 22 nTPM
adipose tissue: 21 nTPM
epididymis: 20 nTPM
endometrium: 18 nTPM

Single-cell type

hepatic stellate cells: 52 nCPM
fibroblasts: 47 nCPM
peritubular myoid cells: 37 nCPM
leydig cells: 36 nCPM
cardiomyocytes: 29 nCPM
ovarian stromal cells: 27 nCPM

Immune cell

non-classical monocyte: 0.8 nTPM
naive B-cell: 0.6 nTPM
memory B-cell: 0.4 nTPM
eosinophil: 0.2 nTPM
intermediate monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

choroid plexus: 16 nTPM
cerebellum: 4.8 nTPM
thalamus: 4.8 nTPM
medulla oblongata: 4.6 nTPM
white matter: 4.5 nTPM
hypothalamus: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.69
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLFML1 as an antibody target. Whether an autoantibody or antibody against OLFML1 could matter depends on whether native OLFML1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLFML1 is annotated as secreted, so native OLFML1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OLFML1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...