Seroatlas · Human Serome Atlas

OLAH

S-acyl fatty acid synthase thioesterase, medium chain

Also known as: FLJ11106, SAST, SAST_HUMAN, THEDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV23
Gene: OLAH
Ensembl: ENSG00000152463
Chromosome: 10
Canonical length: 265 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables fatty acyl-[ACP] hydrolase activity. Involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q9NV23|OLAH
     1  MERGDQPKRT RNENIFNCLY KNPEATFKLI CFPWMGGGST HFAKWGQDTH DLLEVHSLRL
    61  PGRESRVEEP LENDISQLVD EVVCALQPVI QDKPFAFFGH SMGSYIAFRT ALGLKENNQP
   121  EPLHLFLSSA TPVHSKAWHR IPKDDELSEE QISHYLMEFG GTPKHFAEAK EFVKQCSPII
   181  RADLNIVRSC TSNVPSKAVL SCDLTCFVGS EDIAKDMEAW KDVTSGNAKI YQLPGGHFYL
   241  LDPANEKLIK NYIIKCLEVS SISNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLAH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
spleen: 9 nTPM
breast: 5.1 nTPM
esophagus: 3 nTPM
placenta: 3 nTPM
salivary gland: 2.5 nTPM

Single-cell type

breast lactating cells: 1,785 nCPM
early spermatids: 694 nCPM
neutrophils: 635 nCPM
late primary spermatocytes: 278 nCPM
late spermatids: 49 nCPM
medullary thymic epithelial cells: 36 nCPM

Immune cell

neutrophil: 2.6 nTPM
basophil: 0.8 nTPM
plasmacytoid DC: 0.5 nTPM
NK-cell: 0.4 nTPM
memory CD4 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

cerebral cortex: 9.7 nTPM
white matter: 9.4 nTPM
amygdala: 9 nTPM
hippocampal formation: 8.9 nTPM
basal ganglia: 8.4 nTPM
hypothalamus: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.97
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fatty acyl-[ACP] hydrolase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Thioesterase
Alpha/Beta hydrolase fold
Thioesterase domain
Thioesterase type II, NRPS/PKS/S-FAS

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLAH as an antibody target. Whether an autoantibody or antibody against OLAH could matter depends on whether native OLAH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLAH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OLAH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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