OGN
Mimecan
Also known as: MIME_HUMAN, mimecan, OIF, SLRR3A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P20774
- Gene
- OGN
- Ensembl
- ENSG00000106809
- Chromosome
- 9
- Canonical length
- 298 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Endoplasmic reticulum
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Canonical amino-acid sequenceUniProt
298 residues, UniProt reviewed canonical sequence.
>P20774|OGN
1 MKTLQSTLLL LLLVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK
61 ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE
121 SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL
181 KLPVLPPKLT LFNAKYNKIK SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH
241 LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OGN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 367 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 367 nTPM
- ovary: 224 nTPM
- cervix: 203 nTPM
- gallbladder: 154 nTPM
- endometrium: 122 nTPM
- parathyroid gland: 110 nTPM
Single-cell type
- mesothelial cells: 464 nCPM
- fibroblasts: 264 nCPM
- hepatic stellate cells: 252 nCPM
- peritubular myoid cells: 201 nCPM
- ovarian stromal cells: 196 nCPM
- leydig cells: 153 nCPM
Immune cell
- T-reg: 1.7 nTPM
- memory CD4 T-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- myeloid DC: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- NK-cell: 0.1 nTPM
Brain region
- choroid plexus: 24 nTPM
- cerebellum: 9.8 nTPM
- cerebral cortex: 8.9 nTPM
- basal ganglia: 6.6 nTPM
- spinal cord: 5.2 nTPM
- hypothalamus: 5.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.99
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.14
- DepMap mean gene effect
- 0.15
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- articular cartilage development
- bone development
- negative regulation of smooth muscle cell proliferation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OGN as an antibody target. Whether an autoantibody or antibody against OGN could matter depends on whether native OGN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OGN is annotated as secreted, so native OGN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label OGN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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