Seroatlas · Human Serome Atlas

OGFRL1

Opioid growth factor receptor-like protein 1

Also known as: dJ331H24.1, OGRL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TC84
Gene: OGFRL1
Ensembl: ENSG00000119900
Chromosome: 6
Canonical length: 451 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable opioid growth factor receptor activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q5TC84|OGFRL1
     1  MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP AQPPEQAGGR
    61  PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY KYRHQYPNFK DIRYQNDLSN
   121  LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK LEHNHTYIQW LFPLREQGLN FYAKELTTYE
   181  IEEFKKTKEA IRRFLLAYKM MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT
   241  RILKSLGELG YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA
   301  QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK NSSSAVHLNS
   361  KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA ENMNSQPEKT VTTPTEKKES
   421  VSPENNEEGG NDNQDNENPG NTNCHDVVLV Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OGFRL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

breast: 48 nTPM
salivary gland: 44 nTPM
cerebral cortex: 41 nTPM
spinal cord: 32 nTPM
esophagus: 31 nTPM
smooth muscle: 31 nTPM

Single-cell type

schwann cells: 322 nCPM
neutrophils: 316 nCPM
macrophages: 277 nCPM
cdc: 267 nCPM
astrocytes: 266 nCPM
microglia: 230 nCPM

Immune cell

neutrophil: 11 nTPM
basophil: 3.4 nTPM
classical monocyte: 2.6 nTPM
myeloid DC: 2.1 nTPM
intermediate monocyte: 1.7 nTPM
non-classical monocyte: 1.3 nTPM

Brain region

white matter: 154 nTPM
midbrain: 142 nTPM
spinal cord: 130 nTPM
medulla oblongata: 120 nTPM
hypothalamus: 113 nTPM
thalamus: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

opioid growth factor receptor activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Receptor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OGFRL1 as an antibody target. Whether an autoantibody or antibody against OGFRL1 could matter depends on whether native OGFRL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OGFRL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OGFRL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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