Seroatlas · Human Serome Atlas

OGFR

Opioid growth factor receptor

Also known as: Jul-60, OGFR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZT2
Gene
OGFR
Ensembl
ENSG00000060491
Chromosome
20
Canonical length
677 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q9NZT2|OGFR
     1  MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA ARPSSFQSRM
    61  TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE IRFLPNGCFI EDILQNWTDN
   121  YDLLEDNHSY IQWLFPLREP GVNWHAKPLT LREVEVFKSS QEIQERLVRA YELMLGFYGI
   181  RLEDRGTGTV GRAQNYQKRF QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET
   241  LVRRELPGVR QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL
   301  PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV EPQDAGPLER
   361  SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG PQSASEVEKI ALNLEGCALS
   421  QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR VADKVRKRRK VDEGAGDSAA VASGGAQTLA
   481  LAGSPAPSGH PKAGHSENGV EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE
   541  TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE
   601  TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAKAGEA
   661  AELQDAEVES SAKSGKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OGFR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • liver: 76 nTPM
  • spleen: 66 nTPM
  • cerebral cortex: 58 nTPM
  • lung: 53 nTPM
  • prostate: 41 nTPM
  • small intestine: 41 nTPM

Single-cell type

  • kupffer cells: 99 nCPM
  • neutrophils: 75 nCPM
  • monocytes: 75 nCPM
  • extravillous trophoblasts: 73 nCPM
  • hofbauer cells: 66 nCPM
  • cone photoreceptor cells: 64 nCPM

Immune cell

  • eosinophil: 13 nTPM
  • neutrophil: 3.1 nTPM
  • basophil: 1.8 nTPM
  • classical monocyte: 1.5 nTPM
  • naive B-cell: 1.5 nTPM
  • intermediate monocyte: 1.4 nTPM

Brain region

  • cerebral cortex: 55 nTPM
  • white matter: 41 nTPM
  • basal ganglia: 38 nTPM
  • medulla oblongata: 37 nTPM
  • amygdala: 37 nTPM
  • hippocampal formation: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.03
gnomAD missense Z
0.81
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OGFR as an antibody target. Whether an autoantibody or antibody against OGFR could matter depends on whether native OGFR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OGFR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OGFR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OGFR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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