Seroatlas · Human Serome Atlas

OGFOD2

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

Also known as: FLJ13491, FLJ37501, OGFD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6N063
Gene: OGFOD2
Ensembl: ENSG00000111325
Chromosome: 12
Canonical length: 350 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q6N063|OGFOD2
     1  MATVGAPRHF CRCACFCTDN LYVARYGLHV RFRGEQQLRR DYGPILRSRG CVSAKDFQQL
    61  LAELEQEVER RQRLGQESAA RKALIASSYH PARPEVYDSL QDAALAPEFL AVTEYSVSPD
   121  ADLKGLLQRL ETVSEEKRIY RVPVFTAPFC QALLEELEHF EQSDMPKGRP NTMNNYGVLL
   181  HELGLDEPLM TPLRERFLQP LMALLYPDCG GGRLDSHRAF VVKYAPGQDL ELGCHYDNAE
   241  LTLNVALGKV FTGGALYFGG LFQAPTALTE PLEVEHVVGQ GVLHRGGQLH GARPLGTGER
   301  WNLVVWLRAS AVRNSLCPMC CREPDLVDDE GFGDGFTREE PATVDVCALT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OGFOD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
liver: 20 nTPM
pancreas: 20 nTPM
adrenal gland: 14 nTPM
salivary gland: 14 nTPM
kidney: 14 nTPM

Single-cell type

epididymal principal cells: 18 nCPM
ependymal cells: 12 nCPM
tuft cells: 12 nCPM
proximal tubule cells: 6.9 nCPM
astrocytes: 6.5 nCPM
podocytes: 5.9 nCPM

Immune cell

eosinophil: 18 nTPM
non-classical monocyte: 17 nTPM
basophil: 16 nTPM
T-reg: 15 nTPM
memory B-cell: 15 nTPM
intermediate monocyte: 12 nTPM

Brain region

white matter: 15 nTPM
choroid plexus: 14 nTPM
medulla oblongata: 13 nTPM
cerebral cortex: 12 nTPM
pons: 12 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -1.16
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OGFOD2 as an antibody target. Whether an autoantibody or antibody against OGFOD2 could matter depends on whether native OGFOD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OGFOD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OGFOD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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