Seroatlas · Human Serome Atlas

OGFOD1

Prolyl 3-hydroxylase OGFOD1

Also known as: FLJ10826, KIAA1612, OGFD1_HUMAN, TPA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N543
Gene: OGFOD1
Ensembl: ENSG00000087263
Chromosome: 16
Canonical length: 542 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q8N543|OGFOD1
     1  MNGKRPAEPG PARVGKKGKK EVMAEFSDAV TEETLKKQVA EAWSRRTPFS HEVIVMDMDP
    61  FLHCVIPNFI QSQDFLEGLQ KELMNLDFHE KYNDLYKFQQ SDDLKKRREP HISTLRKILF
   121  EDFRSWLSDI SKIDLESTID MSCAKYEFTD ALLCHDDELE GRRIAFILYL VPPWDRSMGG
   181  TLDLYSIDEH FQPKQIVKSL IPSWNKLVFF EVSPVSFHQV SEVLSEEKSR LSISGWFHGP
   241  SLTRPPNYFE PPIPRSPHIP QDHEILYDWI NPTYLDMDYQ VQIQEEFEES SEILLKEFLK
   301  PEKFTKVCEA LEHGHVEWSS RGPPNKRFYE KAEESKLPEI LKECMKLFRS EALFLLLSNF
   361  TGLKLHFLAP SEEDEMNDKK EAETTDITEE GTSHSPPEPE NNQMAISNNS QQSNEQTDPE
   421  PEENETKKES SVPMCQGELR HWKTGHYTLI HDHSKAEFAL DLILYCGCEG WEPEYGGFTS
   481  YIAKGEDEEL LTVNPESNSL ALVYRDRETL KFVKHINHRS LEQKKTFPNR TGFWDFSFIY
   541  YE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OGFOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 29 nTPM
tongue: 22 nTPM
esophagus: 18 nTPM
smooth muscle: 16 nTPM
heart muscle: 14 nTPM
tonsil: 14 nTPM

Single-cell type

epicardial cells: 182 nCPM
thymic myoid cells: 71 nCPM
myonuclei: 55 nCPM
adrenal cortex cells: 50 nCPM
cardiomyocytes: 48 nCPM
megakaryocyte progenitors: 46 nCPM

Immune cell

basophil: 14 nTPM
naive CD4 T-cell: 11 nTPM
MAIT T-cell: 10 nTPM
memory CD4 T-cell: 9.7 nTPM
memory CD8 T-cell: 9.5 nTPM
T-reg: 9.1 nTPM

Brain region

white matter: 21 nTPM
hypothalamus: 18 nTPM
medulla oblongata: 17 nTPM
pons: 17 nTPM
midbrain: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Oxoglutarate/iron-dependent dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain
Prolyl 3,4-dihydroxylase TPA1/OFD1, N-terminal domain
Ribosomal subunit uS12 prolyl hydroxylase
Oxoglutarate and iron-dependent oxygenase degradation C-term
2OG-Fe(II) oxygenase superfamily

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OGFOD1 as an antibody target. Whether an autoantibody or antibody against OGFOD1 could matter depends on whether native OGFOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OGFOD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OGFOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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