Seroatlas · Human Serome Atlas

OFCC1

Orofacial cleft 1 candidate gene 1 protein

Also known as: OFCC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZS5
Gene: OFCC1
Canonical length: 231 aa

OverviewNCBI Gene

No narrative summary is available for OFCC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>Q8IZS5|OFCC1
     1  MEREKFQQKA LKQTKQKKSK SAEFLMVKED REATEGTGNP AFNMSSPDLS ACQTAEKKVI
    61  RHDMPDRTLA AHQQKFRLPA SAEPKGNEYG RNYFDPLMDE EINPRQCATE VSREDDDRIF
   121  YNRLTKLFDE SRQGEPQDES GREETLNSEA PGSSNKSHEI HKEASEATTA HLEEFQRSQK
   181  TIILLGSSPL EQEIRSTSLH CMEDEMSHPW ILLLKVTAVI RSRRYYREQR F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OFCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.27

Protein domainsUniProt · Pfam · InterPro

Orofacial cleft 1 candidate gene 1 protein
Orofacial cleft 1 candidate gene 1 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OFCC1 as an antibody target. Whether an autoantibody or antibody against OFCC1 could matter depends on whether native OFCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OFCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OFCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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