Seroatlas · Human Serome Atlas

ODR4

Protein odr-4 homolog

Also known as: C1orf27, FLJ20505, odr-4, ODR4_HUMAN, TTG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SWX8
Gene: ODR4
Ensembl: ENSG00000157181
Chromosome: 1
Canonical length: 454 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in protein localization. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q5SWX8|ODR4
     1  MGRTYIVEET VGQYLSNINL QGKAFVSGLL IGQCSSQKDY VILATRTPPK EEQSENLKHP
    61  KAKLDNLDEE WATEHACQVS RMLPGGLLVL GVFIITTLEL ANDFQNALRR LMFAVEKSIN
   121  RKRLWNFTEE EVSERVTLHI CASTKKIFCR TYDIHDPKSS ARPADWKYQS GLSSSWLSLE
   181  CTVHINIHIP LSATSVSYTL EKNTKNGLTR WAKEIENGVY LINGQVKDED CDLLEGQKKS
   241  SRGNTQATSH SFDVRVLTQL LLNSDHRSTA TVQICSGSVN LKGAVKCRAY IHSSKPKVKD
   301  AVQAVKRDIL NTVADRCEML FEDLLLNEIP EKKDSEKEFH VLPYRVFVPL PGSTVMLCDY
   361  KFDDESAEEI RDHFMEMLDH TIQIEDLEIA EETNTACMSS SMNSQASLDN TDDEQPKQPI
   421  KTTMLLKIQQ NIGVIAAFTV AVLAAGISFH YFSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 31 nTPM
pancreas: 27 nTPM
salivary gland: 20 nTPM
liver: 20 nTPM
thyroid gland: 19 nTPM
epididymis: 16 nTPM

Single-cell type

pancreatic acinar cells: 176 nCPM
sertoli cells: 122 nCPM
salivary acinar cells: 115 nCPM
breast lactating cells: 112 nCPM
prostatic glandular cells: 101 nCPM
somatotrophs: 99 nCPM

Immune cell

non-classical monocyte: 11 nTPM
NK-cell: 10 nTPM
classical monocyte: 9 nTPM
intermediate monocyte: 8.9 nTPM
myeloid DC: 7.6 nTPM
T-reg: 5.7 nTPM

Brain region

white matter: 25 nTPM
cerebellum: 22 nTPM
medulla oblongata: 20 nTPM
basal ganglia: 20 nTPM
cerebral cortex: 20 nTPM
spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular protein localization

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

ODR-4-like
Odorant response abnormal 4-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODR4 as an antibody target. Whether an autoantibody or antibody against ODR4 could matter depends on whether native ODR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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